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National Institute of Environmental Health Sciences Purchases Hosted Provantis Solution

Provantis Reproductive Toxicology Software Module to be used by National Toxicology Program and Member Organizations

CONSHOHOCKEN, PA - (BUSINESS WIRE) – August 12, 2010 - - Instem®, a leading provider of early drug development software solutions, announced today that the National Institute of Environmental Health Sciences (NIEHS) has purchased the Provantis® preclinical software solution to support the collection, management and maintenance of the reproductive, perinatal and developmental National Toxicology Program (NTP) studies. These studies are done predominantly at contractor laboratories at various sites throughout the United States.

The value of the award to Instem, funded completely by the federal government, is $656,100.

Managed by NIEHS, the NTP is an interagency program whose mission is to evaluate agents of public health concern by developing and applying tools of modern toxicology and molecular biology. The program maintains an objective, science-based approach in dealing with critical issues in toxicology and is committed to using the best science available to prioritize, design, conduct, and interpret its studies.

The NIEHS will be using Instem’s SaaS (Software-as-a-Service) model offering simpler, more cost effective ways to provide software functionality, maintenance, and support over the Internet. Since 2005, Instem has utilized a state-of-the-art data center, which is being used by clients running GLP and non-GLP studies.

Part of the integrated Provantis solution suite, this module will support the NTP reproductive toxicologist or teratologist in conducting all study types, including ICH protocols, multigeneration, developmental toxicity, behavioral and development neurotoxicity studies. Particularly flexible in its design, Instem’s solution supports a full range of data entry types, simplifies the management of event driven studies while enabling NTP program users to generate simple and complex custom reports.

About Provantis®

Provantis is a modern, fully integrated software system for single users and global organizations engaged in preclinical evaluation studies. Orchestrating every facet of preclinical drug safety assessment, Provantis streamlines processes and workflows with straightforward, intuitive functionality for simple or complex studies within a GLP or non-GLP environment, on-site or over the Web.


The NIEHS supports research to understand the effects of the environment on human health and is part of the National Institutes of Health (NIH). Its mission is to reduce the burden of human illness and disability by understanding how the environment influences the development and progression of human disease.
For more information on environmental health topics, visit

The NIH — The Nation's Medical Research Agency — includes 27 Institutes and Centers and is a component of the U.S. Department of Health and Human Services. It is the primary federal agency for conducting and supporting basic, clinical and translational medical research, and it investigates the causes, treatments, and cures for both common and rare diseases. For more information about NIH and its programs, visit

About Instem

Instem is a leading supplier of IT applications to the early development healthcare market, delivering compelling solutions for data collection, management and analysis across the R&D continuum. Instem applications are in use by customers worldwide, meeting the rapidly expanding needs of life science and healthcare organizations for data-driven decision making leading to safer, more effective products.

Instem’s portfolio of software solutions increases client productivity by automating study-related processes while offering the unique ability to generate new knowledge through the extraction and harmonization of actionable scientific information.

Instem supports over 400 clients through full service offices in the United States, United Kingdom and China with additional locations in India and a full service distributor based in Japan.

Meeting clients at the intersection of investment & return™.

Press Contacts:

Gary Mitchell (US HQ)
Tel: 610-941-0990

Julie Jones (UK HQ)
Tel: +44 (0) 1785 825600