What if you could score a comet slide in two minutes?

Comet Assay IV is a live video imaging system designed for fast, accurate and reproducible comet slide scoring.

Comet Assay IV's unique single-click scoring method and instant live video technology make it the most efficient and easy-to-use system available for measuring DNA damage using single cell gel electrophoresis. Comet Assay IV is easy to install and use – simply connect the camera and start scoring.

Comet Assay IV can score many different types of cell; regardless of species, cell size and level of DNA damage. Comet Assay IV uses the parameters defined by Olive et al on the principle of DNA damage and comets are scored appropriately.

When using Comet Assay IV you click on each cell in turn and key comet assay parameters, including % Tail Moment, Tail Length and % hedgehogs will be recorded. Typical time taken to score each slide is less than two minutes.

Comet Assay IV is used across the globe by contract research organisations and pharmaceuticals. It is the market-leading comet scoring system used by academics, with over 66% of comet assay publications written by our customers. Read more about how Comet Assay IV is helping academics create respected, peer-reviewed, scientific investigations & publications.

Comet Assay IV can be used standalone, or together with our genetox study management solution, Cyto Study Manager, to seamlessly bring study management and automated scoring together, as well as a comprehensive audit log to ensure GLP compliance and automated reporting.

You can try Comet Assay IV for one week for free when you download our trial version of the software.

“I have been using the Comet Assay IV software – it is great! During my software validation, I realized how much easier and precise it is compared to our old software. It makes analyzing the comet slides more enjoyable.” Scientist, Medical Research Centre, USA

Key Highlights

Integrated study management – Combine Comet Assay IV with our world-leading genetox study management solution: Cyto Study Manager for fully integrated data collection, management and reporting.

Increase speed – Single click automatic scoring in Comet Assay IV enables you to score comets from a live video. This makes Comet Assay IV the fastest and easiest way to score comets, increasing your laboratory’s productivity.

Boost accuracy – With no adjustable settings or configurations to modify, you can remove subjectivity from the scoring process. Comet Assay IV automatically compensates uneven backgrounds or varying levels of brightness, ensuring comparable and reproducible results across a wide range of slides.

Comprehensive data analysis – Capture and record all  the parameters you need for your analysis, including Tail % DNA, tail moment, tail length and % Hedgehogs.

Reporting – When using Comet Comet Assay IV as a standalone, you can use  our Excel-based tool to chart your Comet assay data, together with powerful macros to compare data across dose ranges.  When using Comet Assay IV together with Cyto Study Manager, reports are created automatically, ensuring you can quickly and easily interpret your results.

Ensure compliance – Work securely in the knowledge that your system is GLP and FDA 21 CFR compliant. For full data security when using Comet Assay IV as a standalone, consider adding Data Extractor and look at the ‘packages comparison’ section of our fact sheet. Data extractor allows you to browse, sort and filter your result and audit data, you can also review, approve or reject your data.

You work to GLP and so do our genetox solutions…

All of Instem’s genetox solutions are designed with reference to the OECD and S2(R1) guidelines. We ensure our solutions are fully compliant with the principles of Good Laboratory Practice (GLP) and the FDA 21 CFR part 11 rule on electronic signatures.

Regulatory Compliance


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