KnowledgeScan™

Expert TSA for Confident Decisions

KnowledgeScan provides robust Target Safety Assessments (TSA) to streamline biological target profiling. This service combines a translational informatics platform, automated processing, and human expertise to drive accurate and rapid TSAs for better decision-making and faster development.

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What is KnowledgeScan?

KnowledgeScan is a specialized TSA service designed to accelerate and improve decision-making in drug development. Instem’s expert team sources data from millions of records, using automation to reduce bias and incorporating expert human insights to ensure reliability and accuracy. By replacing time-consuming and often incomplete manual literature reviews, KnowledgeScan delivers more complete and efficient target safety assessments.

The service is highly flexible and can be applied at any stage of the drug discovery process, from evaluating potential candidates to investigating unexpected preclinical results. Services include a Full TSA and Core TSA tailored to meet your specific needs and internal resources. KnowledgeScan provides the ultimate in TSA capabilities, helping researchers tackle ambitious projects and timelines with confidence.

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Key Benefits of KnowledgeScan

Saves Time

Automated data mining streamlines literature reviews, reducing manual effort and accelerating target safety assessments, freeing you to focus on decision-making, not data gathering.

Reduced Bias

Systematic, automated workflows eliminate human bias, delivering an impartial, comprehensive view of target-related safety across vast literature and toxicology datasets.

Removes Risk

Thorough safety profiling and expert interpretation reduce the chance of overlooking critical toxicology signals, helping to de-risk drug discovery efforts early and safeguard regulatory submissions.

Increases Quality

Every report is curated and validated by scientific experts, ensuring high-quality, accurate insights to support decision-making in drug development.

Expedites Development

Faster, standardized TSAs shorten the time from target selection to go/no-go decisions, helping accelerate drug candidate progression through development pipelines.

Core Features

KnowledgeScan offers a comprehensive suite of features designed to streamline the analysis of bioinformatics, pharmacology, and toxicology data. Its powerful visualizations, transparent methodology, and in-depth reviews across various biological systems provide researchers with the tools they need to make faster, more confident decisions, while also identifying potential knowledge gaps and risks early in the process.

Powerful Visualizations

KnowledgeScan delivers easy-to-read plots that help you quickly interpret large volumes of bioinformatics, pharmacology, and toxicology data. These visuals support faster, more confident decision-making.

Transparent Methodology

Every step in the assessment process is fully traceable and reproducible, giving you confidence in the results and simplifying internal reviews or regulatory submissions.

Knowledge Gaps Identified

The platform identifies missing or underrepresented areas, helping you plan follow-up research and reduce uncertainty in target assessments.

Pharmacology Review

KnowledgeScan analyzes known drug-target interactions, ligand activity, and pharmacodynamic data to predict how modulating a target may affect biological systems.

Physiological Review

The platform evaluates a target’s function in both healthy and disease states, helping researchers understand the full biological impact of therapeutic intervention.

Toxicology & Safety Alerts

Automatically highlights relevant toxicity signals and safety alerts from trusted literature and data sources, helping you mitigate risk early.

Bioinformatics Review

Processes genomic and proteomic data to uncover critical patterns, associations, and unintended target effects.

Systematic Anatomical Review

Reviews target expression across tissues and organs to flag site-specific risks and refine candidate selection strategies.

Why Choose KnowledgeScan?

Manually reviewing literature and toxicology datasets is time-consuming and fails to provide the detail necessary for a robust TSA. This traditional approach can leave teams uncertain about their decisions at a time when they should be moving forward confidently with a well-reviewed and strategically selected target.

KnowledgeScan transforms this process by using computer-aided data acquisition to ensure all relevant information is considered from the start, immediately providing an edge over conventional methods. Furthermore, data is reviewed by Instem’s expert team to verify accuracy, giving you greater confidence in your choices.

KnowledgeScan supports your entire drug development journey, enabling you to refine experiments and optimize processes as new internal and external data emerges. Whether you’re focusing on a single target or seeking an impartial understanding of complex signaling networks, KnowledgeScan is your trusted partner in driving smarter, faster decisions.

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Customer Success Stories

The Challenge:
Haisco Pharmaceutical Group, focused on innovative drug discovery, needed to streamline its TSA process to align with its growth strategy and goals. However, limited published data on novel targets made safety analysis time-consuming and resource-intensive. An efficient, high-quality solution was essential to support rapid R&D decisions.

The Solution:
Haisco partnered with Instem to implement KnowledgeScan. By combining automated data mining, expert review, and standardized reporting, KnowledgeScan was the perfect complement to Haisco’s in-house capabilities. This approach enhanced insight into target-related risks and boosted Haisco’s TSA output.

The Results:

Increased Efficiency – TSA production accelerated significantly and freed scientists from manual data searches.
Improved Decision-Making – Comprehensive, curated reports enabled faster, evidence-based target evaluations.
Resource Optimization – Internal teams focused more on analysis and less on data gathering.

By leveraging KnowledgeScan, Haisco increased TSA capacity, boosted productivity, and built a stronger foundation for confident, well-informed drug discovery decisions.

How It Works

By combining advanced data-mining technology with expert scientific insights, KnowledgeScan provides researchers with reliable, up-to-date toxicological assessments. Here’s how it works to deliver tailored and efficient target safety assessments at every stage of your drug discovery journey.

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1. Consultation

KnowledgeScan begins with a collaborative discussion to help Instem understand your priorities and define project scope.

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2. Knowledge Acquisition

Using advanced data-mining tools, Instem extracts and refines millions of data points from published sources across pharmacology, bioinformatics, and toxicology.

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3. Curation

Our expert scientists classify, tag, and further refine the data to ensure accuracy, relevance, and scientific integrity.

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4. Interpretation (Full TSA)

We analyze and discuss the toxicological significance of findings, drawing evidence-based conclusions to guide decision-making.

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5. Continuous Updates (Full TSA)

You can opt into Evergreen updates to receive regular reports as new data emerges.

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Featured Resources

Our featured blog articles, white papers, and additional materials provide valuable insights, industry trends, and best practices, all aimed at helping you navigate complex safety assessment challenges and make informed decisions throughout the drug discovery process.

Resources

Case Study: Haisco Pharmaceutical Group Strengthens Drug Discovery Processes

Instem Team

KnowledgeScan™ Target Safety Assessment Service Haisco Pharmaceutical Group Strengthens Drug Discovery Processes Setting the Standard in Target Safety Assessment Haisco Pharmaceutical Group Co., Ltd. (Haisco) is a leading Chinese pharmaceutical organization with diverse interests in...

Resources

Case Study: Leading Research Organization Speeds Up Drug Discovery

Instem Team

KnowledgeScan™ Target Safety Assessment Service Leading Research Organization Speeds Up Drug Discovery Setting New Standards in Biological Target Profiling The client is a vibrant science and technology company operating in the healthcare, life science and...

Resources

Brochure: Setting the Standard in Target Safety Assessment

Instem Team

KnowledgeScan™ Target Safety Assessment Service Setting the Standard in Target Safety Assessment Instem’s KnowledgeScan™ Target Safety Assessment Service gives clients detailed insight into the potential toxicological risks and challenges associated with modulating their drug targets,...

Frequently Asked Questions

Find answers to the most commonly asked questions about this service’s features, capabilities, and how it can support your research. Whether you’re getting started with KnowledgeScan for the first time, or looking for specific details, you’ll find the information you need right here.

How is KnowledgeScan deployed?

It is offered as an outsourced service. Clients submit their target of interest, and Instem’s team delivers a comprehensive, standardized assessment report.

Is KnowledgeScan compatible with internal workflows?

Yes. KnowledgeScan reports can complement in-house assessments or be fully outsourced, with options for Full TSA or Core TSA, depending on your needs.

What kind of support can clients expect?

Clients receive ongoing access to scientific experts, including post-report discussions, plus optional Evergreen updates for continuous data monitoring and insights.

How does KnowledgeScan ensure data reliability?

The platform uses reproducible workflows, transparent methodologies, and manual expert review to ensure accuracy, consistency, and scientific integrity in every report.

Get a Free Demo Today

Remove bias, minimize risk, and make smarter decisions with expert-curated reports and powerful, automated insights. Do you want to accelerate development and strengthen regulatory confidence with a better TSA process?

Request your KnowledgeScan demo today.

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