by Candice Johnson, PhD | Jul 17, 2025 | In Silico Insider
This blog explores how protocol-driven (Q)SAR assessments became routine in ICH M7-based impurity evaluations. How ICH M7 Is Applied: Practical Steps for (Q)SAR Mutagenicity Assessment It has been 9 years since the publication of the Principles and Procedures...
by Candice Johnson, PhD | Jun 5, 2025 | In Silico Insider
Excerpt from our presentation titled Applications of Chemical Grouping in Extractables and Leachables (E&L) Risk Assessments at Extractables & Leachables US 2025. In toxicology, chemical grouping supported by clustering approaches offers a science-based...
by Candice Johnson, PhD | May 15, 2025 | In Silico Insider
Instem’s Leadscope Model Applier version 2025.0 introduces enhancements to in silico toxicology, advancing approaches to chemical risk assessment and regulatory compliance. This blog details the newly released features through a scientific lens, with a focus on their...
by Candice Johnson, PhD | Mar 6, 2025 | In Silico Insider
Computational methods are essential for evaluating the potential risks of compounds that lack experimental data, with skin sensitization being a critical endpoint in chemical safety assessments. The integration of knowledge derived from proprietary data sources into...
by Candice Johnson, PhD | Feb 27, 2025 | In Silico Insider
Accurately predicting the toxicity and potency of compounds like N-nitrosamines is crucial. The Carcinogenic Potency Categorization Approach (CPCA) calculators, as developed by various health authorities, have been used to derive Acceptable Intake values for...
