by Candice Johnson, PhD | Sep 11, 2025 | In Silico Insider
The International Collaboration on Cosmetic Safety (ICCS) recently published its Best Practice Guidance (BPG) Document for skin sensitization assessment using New Approach Methods (NAMs) for substances in cosmetics and personal care products1. This BPG... 
by Candice Johnson, PhD | Aug 7, 2025 | In Silico Insider
In the evolving landscape of chemical safety and regulatory science, the assessment of endocrine-disrupting chemicals (EDCs) has become a critical priority. Endocrine disruption (ED) has been introduced as a classification and labelling category in Regulation (EC) No... 
by Candice Johnson, PhD | Jul 17, 2025 | In Silico Insider
This blog explores how protocol-driven (Q)SAR assessments became routine in ICH M7-based impurity evaluations. How ICH M7 Is Applied: Practical Steps for (Q)SAR Mutagenicity Assessment It has been 9 years since the publication of the Principles and Procedures... 
by Candice Johnson, PhD | Jun 5, 2025 | In Silico Insider
Excerpt from our presentation titled Applications of Chemical Grouping in Extractables and Leachables (E&L) Risk Assessments at Extractables & Leachables US 2025. In toxicology, chemical grouping supported by clustering approaches offers a science-based... 
by Candice Johnson, PhD | May 15, 2025 | In Silico Insider
Instem’s Leadscope Model Applier version 2025.0 introduces enhancements to in silico toxicology, advancing approaches to chemical risk assessment and regulatory compliance. This blog details the newly released features through a scientific lens, with a focus on their... 