NOTOCORD-hem™
Accelerating Physiological Data Collection, Analysis, and Reporting
NOTOCORD-hem is a comprehensive software platform for assessing physiological functions across cardiovascular, respiratory, and nervous system applications for nonclinical and life science academic research. This GLP-compliant solution allows researchers to leverage over 160 advanced modules to acquire and analyze physiological data while instantly generating custom reports.
Achieve security, efficiency, and compliance with any experimental setup. Request your NOTOCORD-hem demo today!
What is NOTOCORD-hem?
NOTOCORD-hem is a powerful software platform built to efficiently acquire, visualize, and analyze physiological signals across diverse research areas, including cardiovascular, respiratory, and nervous system studies. It enables data collection from various animal species, whether conscious or anesthetized, and across in vivo, in vitro, and ex vivo conditions, including implantable, organ bath, and patch clamp systems.
Nonclinical R&D produces large volumes of complex data from various hardware devices, making integration and management challenging, particularly under strict regulatory standards. NOTOCORD-hem streamlines this process by supporting complex experimental setups and ensuring compatibility with diverse instruments. It also safeguards data integrity even in vast quantities, with all information stored in a single, compressed file, exceeding 10 GB if needed. These features help researchers accelerate study timelines, reduce compliance risk, and manage complex data with greater ease and confidence.
Key Benefits of NOTOCORD-hem
Increased Efficiency
NOTOCORD-hem enables researchers to simultaneously collect and process large volumes of varied data. It supports multi-animal acquisition using automated data capture modules, with streamlined exporting to Microsoft Excel® for speedy reporting.
Seamless Integration
With broad hardware compatibility, NOTOCORD-hem fits easily into existing lab setups, supporting digital and analog signal acquisition from various devices.
Adaptive Flexibility
NOTOCORD-hem’s extensive suite of modules means researchers can build customized systems to fit niche research objectives and non-standard experimental configurations. Its simple interface and versatility across species, procedures, and study types help reduce configuration complexity and shorten learning curves for researchers.
Improved Compliance and Security
Built for regulated environments, NOTOCORD-hem ensures full GLP compliance and supports 21 CFR Part 11 requirements with features like audit trails, electronic signatures, and controlled access.
Core Features/Modules
With over 160 modules, NOTOCORD-hem offers flexibility and functionality to support virtually any research aim.
Cardiovascular System
The platform includes specialized modules for cardiovascular research, covering ECG analysis and arrhythmia detection, hemodynamic assessments, baroreflex evaluation, and heart rate variability analysis.
Nervous System
NOTOCORD-hem covers modules for central and peripheral nervous system research, offering EEG analysis for detecting epileptic events, EMG recording to monitor muscle activity, calculations on activity indices, and soon supporting sleep studies!
Respiratory System
NOTOCORD-hem supports plethysmography and pneumotachography experiments, including the DTS60a module for capturing analog signals via BNC outputs. Also when it comes to implantable telemetry, we have the RFP10a module for measuring respiratory rate.
Ex Vivo
NOTOCORD-hem facilitates capture of monophasic action potential (MAP), ECG, flow, pressures, and more, to enable advanced ex vivo cardiovascular studies. It also supports tissue or organ bath assays.
In Vitro
NOTOCORD-hem supports patch clamp assays including cardiac action potential assays and GLP ion channel assays like the hERG assay which is mandatory for an IND.
Video Solutions
NOTOCORD-hem offers reliable cameras and acquisition modules to support telemetry studies, allowing researchers to synchronize video recordings with ECG data. It also includes secure video archiving and encryption features to protect sensitive data.
Hardware Compatibility
NOTOCORD-hem is compatible with the most widely used hardware systems in R&D, including Data Translation A/D cards and HD digital video cameras, among many others.
Why Choose NOTOCORD-hem?
NOTOCORD-hem offers researchers a unified platform that supports various experimental setups, eliminating the need to manage multiple software solutions. The platform simplifies workflows, ensures compatibility, and helps researchers meet regulatory requirements.
In contrast, other solutions often require expensive investments in multiple software packages, without guaranteeing hardware compatibility, potentially resulting in the purchase of redundant software or incompatible devices. NOTOCORD-hem provides a centralized, cost-effective alternative, with over 160 modules tailored to modern research requirements.
Instem provides rapid assistance for technical issues and guidance on maximizing the software’s potential. This includes help with building Excel macros to streamline reporting and enhance research productivity, providing clients with a stronger return on investment.
NOTOCORD-hem delivers powerful functionality without introducing unnecessary complexity, thanks to its intuitive interface that ensures easy use and seamless integration into lab workflows from day one.
How It Works
NOTOCORD-hem™ simplifies physiological data acquisition and analysis through a modular, customizable platform compatible with a wide range of hardware. The intuitive interface and flexible architecture support efficient workflows in cardiovascular, respiratory, and nervous system research.
Build the Configuration
Create comprehensive study protocols with built-in templates and configurable options for GLP and non-GLP settings. Users can include test article information, animal data, and activity schedules.
Acquire Experimental Data
Capture in-life and pathology data directly with intuitive, clickable options, reducing errors and saving time. Real-time dose calculations and histology data processing are supported.
Display Signals
Provantis conducts daily checks for data completeness and validity, with all corrections logged in the audit trail. It facilitates seamless collaboration and peer reviews, avoiding bottlenecks and improving workflow efficiency.
Analyze and Review Data
Conduct descriptive and diagnostic data analysis and generate statistical summary reports to monitor progress and compile final data for regulatory submissions.
Report in Microsoft Excel
The Microsoft Excel wizard facilitates rapid data extraction and reporting while maintaining full traceability.
Frequently Asked Questions
NOTOCORD-hem offers extensive functionality, so it’s natural for customers to have questions about how it fits their needs. Here are answers to some of the most common questions we receive about how it supports diverse R&D goals.
Is NOTOCORD-hem compliant with regulatory standards?
Yes, it is compliant with GLP standards and 21 CFR Part 11, offering features such as access control, audit trails, and electronic signatures.
Is NOTOCORD-hem an industry-standard solution?
Yes. With over 1,500 licenses worldwide, NOTOCORD-hem is a trusted platform used by leading pharmaceutical and biotech companies and research institutions.
Can Customers use existing systems with NOTOCORD-hem?
Yes, it is our priority to make NOTOCORD-hem compatible with all analog amplifiers and systems. As long as they have analog outputs, they will connect to this solution.
What types of experiments does NOTOCORD-hem support?
The software supports a wide range of setups, including in vivo, in vitro, and ex vivo studies, with both conscious and anesthetized animals using implants or organ bath, and patch clamp systems.
Can I use multiple devices in the same setup?
Yes. NOTOCORD-hem supports simultaneous acquisition from various sources, allowing flexible configurations across diverse hardware systems.
Get a Free Demo Today
Remove concerns over hardware compatibility, data acquisition, and compliance by leveraging NOTOCORD-hem, a centralized, industry-standard solution for cardiovascular, respiratory, and nervous system research.
Request a demo today to see how this easy-to-use platform streamlines even the most complex experimental setup without added complexity or compromise in performance.