by Candice Johnson, PhD | Mar 6, 2025 | In Silico Insider
Computational methods are essential for evaluating the potential risks of compounds that lack experimental data, with skin sensitization being a critical endpoint in chemical safety assessments. The integration of knowledge derived from proprietary data sources into...
by Candice Johnson, PhD | Feb 27, 2025 | In Silico Insider
Accurately predicting the toxicity and potency of compounds like N-nitrosamines is crucial. The Carcinogenic Potency Categorization Approach (CPCA) calculators, as developed by various health authorities, have been used to derive Acceptable Intake values for...
by Candice Johnson, PhD | Feb 21, 2025 | In Silico Insider
The ability to assess acute oral toxicity accurately is necessary for ensuring the safety of chemicals. One of the most effective ways to enhance computational predictions of acute oral toxicity is by leveraging the power of large databases of experimental data. This...
by Candice Johnson, PhD | Jan 15, 2025 | In Silico Insider
International harmonization guidelines in the context of toxicity assessments are crucial for establishing consistent safety standards, ensuring efficient regulatory compliance, and streamlining product approvals across regions. There are several areas where...
by Candice Johnson, PhD | Dec 12, 2024 | In Silico Insider
In today’s toxicology landscape, in silico profiling has emerged as a powerful approach for providing insights into the toxicity profile of chemicals, specifically their toxicological characteristics. In silico toxicity profiling involves the use of...
