News & Events

In this section

Instem Receives Award from National Institute of Environmental Health Sciences

Provantis Preclinical Software Chosen for National Toxicology Program

CONSHOHOCKEN, PA - (BUSINESS WIRE) - March 4, 2013 - - Instem, a leading provider of IT solutions to the global early development healthcare market, announced today that The National Institute of Environmental Health Sciences (NIEHS), part of the National Institutes of Health (NIH), has purchased the Provantis® preclinical software suite to support National Toxicology Program studies. These Reproductive, Immunotox, Neurobehavioral, Sensitization and Carcinogenicity studies are primarily carried out at contractor laboratory sites throughout the United States.

The National Toxicology Program (NTP) is an interagency program established in 1978 to coordinate toxicology research and development across the Department of Health and Human Services. The program was also created to strengthen the science base in toxicology, develop and validate improved testing methods and provide information about potentially toxic chemicals to health regulatory and research agencies, scientific and medical communities, and the public.
Headquartered at NIEHS, the NTP is managed by the NIEHS and supported by the United States Food and Drug Administration and the Centers for Disease Control and Prevention.

Key Facts

  • Provantis modules purchased by NIEHS include General Toxicology, Reproductive Toxicology, Pathology, Tables & Statistics, Protocol & Report Assembly, and Data Import
  • NIEHS to implement Provantis 9; the latest version of Instem’s preclinical software suite
  • Instem SaaS model to provide on-demand Internet-based access to NIEHS and member sites
  • Value of  year-1 base award to Instem, funded completely by the federal government, is $869,886; with potential to extend and expand agreement up to a further 9 years, giving possible total 10-year contract value of between $6,185,633 -$7,619,981
  • NIEHS agreement also includes ability to expand program to larger number of additional contractor laboratory sites across the United States which could result in further substantial award revenue

Phil Reason, President & CEO Instem commented, “This is a very proud moment for Instem. Such a significant contract with the NIEHS, won through a competitive tendering process, is not only a fantastic endorsement of Instem’s innovative Study Workflow & Automation software suite but also of our strategy to support collaborative working practices. The accessibility of Provantis data by a diverse NTP community via our SaaS delivery model will also enable the NIEHS to meet a key goal of combining study information with a broader set of biology information to improve scientific insights.”

This project has been funded in whole or in part with Federal funds from the National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, under Contract No. HHSN27320130004C.


The NIEHS supports research to understand the effects of the environment on human health and is part of the National Institutes of Health (NIH). Its mission is to reduce the burden of human illness and disability by understanding how the environment influences the development and progression of human disease.
For more information on environmental health topics, visit

The NIH — The Nation's Medical Research Agency — includes 27 Institutes and Centers and is a component of the U.S. Department of Health and Human Services.
It is the primary federal agency for conducting and supporting basic, clinical and translational medical research, and it investigates the causes, treatments, and cures for both common and rare diseases. For more information about NIH and its programs, visit

About Instem

Instem is a leading supplier of IT applications to the early development healthcare market, delivering compelling solutions for data collection, management and analysis across the R&D continuum. Instem applications are in use by customers worldwide, meeting the rapidly expanding needs of life science and healthcare organizations for data-driven decision making leading to safer, more effective products.

Instem’s portfolio of software solutions increases client productivity by automating study-related processes while offering the unique ability to generate new knowledge through the extraction and harmonization of actionable scientific information.

Instem supports over 400 clients through full service offices in the United States, United Kingdom and China with additional locations in India and a full service distributor based in Japan.

Meeting clients at the intersection of investment & return™.

Press Contacts:

Gary Mitchell (US HQ)
Tel: 610-941-0990

Julie Jones (UK HQ)
Tel: +44 (0) 1785 825600